Wakefield’s Lancet Paper Vindicated – [Yet Again]

[STOP PRESS: New papers keep emerging - see additions below 22nd May & 5th June 2010]

New independent research presented at the 2010 Pediatric Academic Societies Annual Meeting in Vancouver, Canada confirms unequivocally the findings of Dr Andrew Wakefield’s 1998 Lancet paper of an association between autism and serious gastrointestinal disease in children [Full Details Below].

And do vaccines cause autistic conditions?  If you read nothing else we strongly recommend you read this PDF Download:– Text of email from US HRSA to Sharyl Attkisson of CBS News].  In it the US Health Resources Services Administration [HRSA] state to CBS News reporter Sharyl Attkisson

We have compensated cases in which children exhibited an encephalopathy, or general brain disease. Encephalopathy may be accompanied by a medical progression of an array of symptoms including autistic behavior, autism, or seizures.

Despite all the lies and deceit by health official worldwide, the question was answered when the Hannah  Poling story broke in the USA [see CHS article here].  Hannah developed an autistic condition after 9 vaccines administered the same day.  Under the media spotlight the question was answered by numerous US health officials and agencies and broadcast on nationwide TV news from CBS and CNN.  The answer is “Yes”. Full details with links to the original sources can be found in this CHS article: Vaccination Causes Autism – Say US Government & Merck’s Director of Vaccines. [Blue Text added 10 April 2011]

The new study was conducted by the Autism Speaks Autism Treatment Network and covered data from 15 treatment and research centers in the United States and Canada.  Of 1185 children aged 2 to18 years with an autistic condition 45% were reported to have GI symptoms. Abdominal pain was most common (59%) followed by constipation (51%), diarrhea (43%), other (40%), nausea (31%) and bloating (26%). Reports of GI symptoms increased with age.  Sleep problems occurred in 70% of children with than those without GI symptoms (30%).  The problems affected all children regardless of gender, ethnic background or intelligence.

Wakefield’s 1998 Lancet case series on 12 children stated:

Interpretation: We identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.”

A J Wakefield, S H Murch, A Anthony, J Linnell, D M Casson, M Malik, M Berelowitz, A P Dhillon, M A Thomson, P Harvey, A Valentine, S E Davies, J A Walker-Smith “Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children” THE LANCET • Vol 351 • February 28, 1998. The Lancet paper was retracted by The Lancet after the General Medical Council decision in January 2010 in the case of Professors Walker-Smith, Simon Murch and Mr Andrew Wakefield.  [Added 26 May 2010].

But this is not the first time Wakefield’s research has been confirmed by independent researchers around the world.  Read a previous article and see the list of papers replicating Wakefield’s Lancet paper research: Sunday Times’ Discredited – Wakefield’s Autism Research Verified

And another recently published paper in Pediatrics Journal by 27 authors confirms a medical consensus that

Gastrointestinal disorders and associated symptoms are commonly reported in individuals with ASDs, but key issues such as the prevalence and best treatment of these conditions are incompletely understood.”

Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs:PEDIATRICS Volume 125, Supplement 1, January 2010 [Added 22 May 2010].

And yet another just published paper [3 June 2010] from researchers at Imperial College, London also supports Wakefield and Walker-Smith’s original finding.

People with autism are also known to suffer from gastrointestinal disorders and they have a different makeup of bacteria in their guts from non-autistic people. Today’s research shows that it is possible to distinguish between autistic and non-autistic children by looking at the by-products of gut bacteria and the body’s metabolic processes in the children’s urine. The exact biological significance of gastrointestinal disorders in the development of autism is unknown

Children with autism have a different chemical fingerprint in their urine than non-autistic children, Imperial College News Release Thursday 3 June 2010, “Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls,” Journal of Proteome Research, published in print 4 June 2010. [Added 5 June 2010]

Additionally, one of the witnesses in the GMC proceedings against Dr Wakefield writing to the British Medical Journal confirmed the validity of the histopathology on which the paper was based and illustrated how Sunday Times journalist Brian Deer had misrepresented her evidence.  Dr Susan E Davies, Consultant Histopathologist, Addenbrooke’s Hospital, Cambridge stated in the British Medical Journal regarding a BMJ article by Brian Deer that:

There is some misrepresentation …. and lack of understanding of the process in studies involving histopathology.” and that there were significant findings “While a clinical gastroenterologist might consider caecal active inflammation with incipient crypt abscess formation to be normal in children (1), this is a significant finding to be recorded by pathologists

Caution in assessing histopathological opinions.” BMJ Rapid Responses 30 April 2010.

So will Dr Richard Horton, editor of The Lancet now “unretract” The Lancet paper?

Read the abstract of the new US research vindicating Wakefield’s work here:

[2320.7] GI Symptoms in Autism Spectrum Disorders (ASD): An Autism Treatment Network Study

Kent Williams, George J. Fuchs, Glenn Furuta, Margaret Marcon, Daniel L. Coury, Autism Treatment Network GI Committee. Vanderbilt University, Nashville, TN; University of Arkansas for Medical Sciences, Little Rock, AK; University of Colorado at Denver, Denver, CO; Hospital for Sick Children, Toronto, Canada; Nationwide Children’s Hospital, Columbus, OH.

BACKGROUND: The prevalence of GI symptoms in children and adolescents with ASD is uncertain, with studies reporting conflicting results.

OBJECTIVE: To determine the frequency of GI symptoms as reported by parents in a large ASD registry, and to identify factors associated with GI symptoms in children with ASD.

DESIGN/METHODS: Autism Treatment Network Registry enrolled 1420 children, age 2-18 years, with an ADOS-confirmed ASD diagnosis (autism, Asperger disorder, or PDD-NOS) at 15 sites in the US and Canada. Parents completed a GI symptom inventory tailored to the needs of nonverbal children, as well as Child Behavior Checklist (CBCL), Child Sleep Health Questionnaire (CSHQ) and Pediatric Quality of Life (PedsQL) at time of enrollment.

RESULTS: GI symptom data were available for 1185 children. Overall 45% of children were reported to have GI symptoms at time of enrollment. Of GI complaints that occurred within the 3 months prior to enrollment, abdominal pain was most common (59%) followed by constipation (51%), diarrhea (43%), other (40%), nausea (31%) and bloating (26%). Reports of GI symptoms increased with age, ranging from 39% in those under 5 years to 51% in those 7 years and older (p<0.0001). Children ages 1 to 5 years with GI symptoms had higher CBCL t-scores for total problems and for the emotionally reactive, anxious/depressed, somatic complaints, sleep problems, internalizing problems, affective problems, and anxiety problems subscales, all p<0.05. Children ages 6 to 18 years with GI symptoms had higher CBCL t-scores for total problems and for all subscales (p<0.01). Sleep problems occurred more frequently in children with than those without GI symptoms (70% versus 30%, p<0.0001). Children with GI symptoms had lower PedsQL scores (overall score and all five subscales, p<0.01) compared to children without GI problems. Presence of GI problems did not differ by gender, ASD subtype, race, or IQ.

CONCLUSIONS: Parents of children with ASD report a high prevalence of GI symptoms in their children. This prevalence increases with age. GI complaints are significantly associated with behavioral abnormalities in all age groups. GI symptoms are also significantly associated with sleep disturbances and decreased health-related quality of life. Further definition is needed on the role and potential impact of treatment of GI disorders on behavior, sleep disturbance, and quality of life in children with ASD.

Date: Sunday, May 2, 2010
Poster Symposium Session: Autism (10:15 AM – 12:15 PM)
Presentation Time: 10:15 AM
Room: East Ballroom C – Vancouver Convention Centre
Board Number: 7
Course Number: 2320

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27 Responses

  1. Thanks for this report, childhealthsafety. It’s important to keep on top of the studies on ASD, and cross-reference them. Too many commentators out there still seem to think that there is no evidence for these matters, that ‘all the studies show…’. Many of those epid studies show the hand of those who don’t WANT there to be a connection, between such as gut damage and autism, and gut damage in association with vaccines. A dangerous – to them – outcome. It might cause – finally – this matter to be blown wide open.

  2. ED Note:

    The comment here is from a well-known internet troll who has come to this site a number of times and sometimes even posing as a woman and engaging in the usual abuse and obscenities which has come to be the norm for these people and which is not tolerated on any responsible sites.

    For the amusement of all therefore we only think it fair to post this comment from the person concerned:

    Another anti-vax website where censorship is the best you can do.

    Intellectual cowards.

  3. Well known troll? Hardly. I know it is easier for anti-vaccination lair to marginalize those with whom they disagree, but a troll? No. Try a pain in the arse. I will admit to that, since it the easiest way to get to the anti-vaxxers brain.

    If you had a shred of intellectual honesty you would have posted my previous comments and then posted what you would.

    Simply put, you people cannot handle the truth.

    [ED: The author of this post Mark Probert is not just a well-known internet troll. He operates from a major world Pharmaceutical Industry centre, as his IP address reveals. See details of the IP address here:

    http://newsgroups.derkeiler.com/Archive/Misc/misc.health.alternative/2009-08/msg01226.html

    The IP address for Mark Probert 64.61.170.226 resolves to a town in the US called King of Prussia.

    Guess which companies are found there? Smith Kline Beecham with one of its major manufacturing sites:-

    http://www.gsk.com/research/about/about_locationsus.html

    And who else?

    Merck [and its related company CSL whose flu vaccine was pulled from under 5 year old children in Australia recently on safety concerns], Aventis Behring, CSL Behring, MDS Pharma Services, Elan Pharmaceuticals, Glaxosmithkline, Abbott Labaoratories Administrative, Hospira Worldwide.

    Of course this could well be just a coincidence and we do not suggest there is any connection direct or indirect.]

  4. [...] The new study was conducted by the Autism Speaks Autism Treatment Network and covered data from 15 treatment and research centers in the United States and Canada.  Of 1185 children aged 2 to18 years with an autistic condition 45% were reported to have GI symptoms. Abdominal pain was most common (59%) followed by constipation (51%), diarrhea (43%), other (40%), nausea (31%) and bloating (26%). Reports of GI symptoms increased with age.  Sleep problems occurred in 70% of children with than those without GI symptoms (30%).  The problems affected all children regardless of gender, ethnic background or intelligence. http://childhealthsafety.wordpress.com/2010/05/06/wakefield%E2%80%99s-lancet%C2%A0paper%C2%A0vindica… [...]

  5. A survey of parents of kids with and with autism for GI symptoms does nothing to prove any aspect of Wakefield’s 1998 paper because, amongst other points, children selected for the 1998 paper were supposed to have autism and sufficient GI symptoms that a colonoscopy was warranted.

    That aspect of the 1998 paper would be true whether autistic children had fewer, the same, or more GI symptoms than non-autistic children.

    [ED: Read it again, Prof Sheldon101.]

  6. This blog entry is dated May 6, 2010. On May 12, 2010, Brian Deer’s response to Dr. Davies was posted on the BMJ website at

    http://www.bmj.com/cgi/eletters/340/apr15_2/c1127

    [ED: Oh, you mean the response of expert histopathologist Professor Brian Deer, Sunday Times journalist who has no scientific or technical qualifications, who seems also to be an expert professor of neurology, psychiatry, psychology, gastroenterology and all else medical without ever attending med school.

    And Deer's "12 May" response was posted on or before 6th May but it seems for some reason the BMJ held up publishing it until 12th May when they say "Rapid Responses" are supposed to be published within 24 hours. Looks like even they could see problems with publishing it.]

  7. Thanks for allowing my comments to stand.

    You provided the objectives of the 2010 study:
    ” To determine the frequency of GI symptoms as reported by parents in a large ASD registry, and to identify factors associated with GI symptoms in children with ASD”

    You haven’t provided any reason why any results from this survey are relevant to Wakefield’s theory. The theory was that measles vaccine virus caused persistent infection in the gut that somehow or another ended up causing autism.

    As to Brian Deer, I just added a reference to his response. As a matter of fairness, you should add it to the main blog entry.

    [ED: You make an ass of yourself all over the Huffington Post and now you come here to do the same. The Royal Free Hospital’s 1998 Lancet paper was about children with autism and serious bowel disease. It was the first paper to flag this up and has now been replicated and supported in numerous peer reviewed studies.

    You come here without a single medical qualification to your name to contradict numerous peer reviewed papers to tell the world otherwise and you have not even read the paper you claim to be contradicting.

    You were banned from this site previously for coming here using a made up name and accusing others of being liars:

    http://childhealthsafety.wordpress.com/contact/#comment-2127%5D

  8. [...] the Rotavirus vaccine and HPV- Cervix cancer vaccines;   and the evidence-based vindication of Dr Andrew Wakefield’s work and martyrdom on  damage inflicted by multiple early vaccinations .  For example, the [...]

  9. [...] the Rotavirus vaccine and HPV- Cervix cancer vaccines;   and the evidence-based vindication of Dr Andrew Wakefield’s work and martyrdom on  damage inflicted by multiple early [...]

  10. [...] via Wakefield’s Lancet Paper Vindicated – [Yet Again] « ________________Child Health Safety______…. [...]

  11. [...] New independent research presented at the 2010 Pediatric Academic Societies Annual Meeting in Vancouver, Canada confirms unequivocally the findings of Dr Andrew Wakefield’s 1998 Lancet paper of an association between autism and serious gastrointestinal disease in children. The new study was conducted by the Autism Speaks Autism Treatment Network and covered data from 15 treatment and research centers in the United States and Canada.  Of 1185 children aged 2 to18 years with an autistic condition 45% were reported to have GI symptoms. Abdominal pain was most common (59%) followed by constipation (51%), diarrhea (43%), other (40%), nausea (31%) and bloating (26%). Reports of GI symptoms increased with age.  Sleep problems occurred in 70% of children with than those without GI symptoms (30%).  The problems affected all children regardless of gender, ethnic background or intelligence. http://childhealthsafety.wordpress.com/2010/05/06/wakefield%E2%80%99s-lancet%C2%A0paper%C2%A0vindica… [...]

  12. [...] hysteria was recently found to have totally doctored his findings. Not a bit of truth to it. Wakefield Wakefield was vindicated and it was proved that what he said was indeed [...]

  13. http://childhealthsafety.wordpress.com/2010/05/06/wakefield%e2%80%99s-lancet%c2%a0paper%c2%a0vindicated/

    I think that rather than Dr Wakefield’s research findings being shown to be fraudulent, the reverse is true, that his findings were indeed vindicated regarding the link between vaccination and autism.

  14. I have been very peripheral to the MMR/autism controversy since the Wakefield Lancet article came out in 1998. Recently I have become more interested in a variety of controversial issues in regard to the science upon which the controversies are based. My background is in both research (have an earned PhD from a reputable US University) and Surgery (have a DO degree and a full fledged surgical residency). I have recently had a look at the original Wakefield paper and the GMC findings in regard to Wakefield’s work. I make no statements here about whether there is a link between autism and MMR. I am making a statement about the Wakefield paper. It is unfitting to have ever been in the scientific literature and Lancet should feel shamed for ever publishing it. If a link exists it was certainly not demonstrated by Wakefield’s paper. Those seeking a cause for autism should leave Wakefield out of the discussion or they simply make themselves look bereft of how to examine scientific research.

  15. Whether or not you have a PhD ‘from a reputable US University’ (sounds like pompous fraudulent BS to me, would you care to name that university?) is entirely besides the point, and you merely troll here rather that qualifying your pathetic assertion about the Wakefield Paper. You have a ‘full fledged surgical residency’ my ass, the most surgery you have ever attempted is on your Sunday lunch, or pulling wings off helpess little flies. Tell us all another story.

  16. Bottom line. This study does nothing to ‘vindicate’ Wakefield’s claims that MMR causes autism. All you’re citing is information stating that individuals with autism have GI differences. In no way does that have anything to do with the vaccine. Wakefield has caused a public health crisis in which parents are abusing their children by not vaccinating them. Look at the actual data… autism rates are increasing while vaccination rates have decreased.

    Don’t punish your children just because you aren’t able to objectively read and digest scientific information.

    [ED: Wakefield et al published in 1998 that they investigated a consecutive series of "12 children .... with a history of normal development followed by loss of acquired skills, including language, together with diarrhoea and abdominal pain." And they found "We identified associated gastrointestinal disease and developmental regression in a group of previously normal children ...."

    The authors stated: "We have identified a chronic enterocolitis in children that may be related to neuropsychiatric dysfunction. ..."

    The paper was an "early report" which stated "Further investigations are needed to examine this syndrome ....".

    And now everyone is agreeing that autistic children do, as they found, have gastroenterological conditions in far greater numbers than other children. It was a new discovery.

    As for the link to the vaccine. This was wrong because it seems it is not just the MMR vaccine which causes autistic conditions but many vaccines as the US Government health agencies and Merck's Director of Vaccines Division have conceded publicly on advice from the medical and scientific experts. You can read about it with source references here: Vaccination Causes Autism – Say US Government & Merck’s Director of Vaccines].

    So Mr/Ms “Exterminator”, maybe it is time the medical professions stopped these abuses of children and their lives.

  17. I’ve attempted to compile a relatively short report about the Lancet paper/Wakefield situation for anyone who may not be aware.

    Note: I’ve read the Lancet paper & the transcript of the original press release about the paper on Brian Deers website & have heard Wakefields side of the story in multiple interviews… at least 10… I’ve listened to/read the claims of the left, the right & the middle… I have a base understanding of the court cases… some numbers & dates have been approximated as i am not certain the figures are exactly correct

    In the earlier part of the 90’s Wakefield was known for his work on Chrohns Disease in the UK & parents of autistic children began to contact him because they could not get effective help for their children from other doctors & their children had symptoms that were similar to Chrohns Disease. Because Wakefield was a researcher, he referred the children to Walker-Smith for clinical treatment. Walker-Smith was the world leading gastro intestinal doctor at the time. Eventually, a group of doctors/researchers involved in the treatment of these children published the controversial Lancet paper in 1998 which was an “early report” on the clinical/treatment findings on 12 child patients with autism & gastro disease… It was not a study that set out to prove or disprove a hypothesis, but more likely was a declaration of a hypothesis that deserved testing… it raised questions. Wakefield claims that approximately 19 more papers were subsequently published, but I am not aware of their content at this time & the media, as far as I know has not shown any interest in reporting anything about them.

    So what was in the original Lancet paper?

    As stated in the article above, the official conclusion of the paper was: “We identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.”

    The paper mentions that the majority, not all, appx 9 of the 12 PARENTS claimed their childrens regression began immediately following the MMR.

    The paper also stated in abundant clarity that the clinical investigation did not prove any causation of anything, but that the possible link to the MMR should be studied to quell concerns.

    The paper also includes evidence of the childrens bowel conditions & links their gastro intestinal disease to their regression, “scientific” data that is rarely discussed in the public forum, including images.

    Shortly after this paper was published in the Lancet, there was a press release interview at which Wakefield spoke… he never said in the press interview that the MMR caused autism, the interviewing reporter is the one who emphasized the connection … in response to further questioning, Wakefield recommended, that until more is known, that it would be worth considering recommending that parents choose the single shots in place of the triple MMR shot, until more is known… the single shots were readily available & legal at the time he made this suggestion, however, less than a year later, the UK govt banned the single shots from the market.

    Eventually, a year or two later, Wakefield claims that the the team was asked to remove the data in the original Lancet paper about what the parents claimed about the MMR & that it needed to be investigated … 3 of the authors, Walker-Smith, Mursh & Wakefield would not agree to remove it, as they felt it would be unethical not to include this pertinent information … the other writers removed their names from the paper, (start opinion) likely under some kind of duress of sorts (end opinion) after their refusal, Wakefield was pretty much “encouraged” to leave his post at the Royal Free hospital, Walker-Smith retired & I do not know what happened to Murch.

    After leaving the Royal Free, Wakefield went to the US & sometime around 2001, a freelance reporter, Brian Deer, managed to publish an article in a prominent British newspaper, “The Sunday Times” making accusatory claims about Wakefield… then the reporter filed charges against Wakefield with the General Medical Council (GMC) in the UK & they eventually found Wakefield, Mursh & Walker-Smith guilty on “professional misconduct” charges. Because of this, the Doctors lost their licenses.

    Soon thereafter, Walker Smith won an appeal case & had his conviction overturned. The court admonished the actions of the GMC.

    As of Aug 2012, Wakefield is attempting to sue Brian Deer & The British Medical Journal & it’s publisher for libel in a Texas court… He has written two books, “Callous Disregard: The Truth Behind the Tragedy” about the Lancet paper & subsequent experiences & “Waging War on the Autistic Child: The Arizona 5 and the Legacy of Baron von Munchausen” about a group of 5 children identified with autism who were taken away from their parents after the parents successfully improved their conditions greatly using biomedical interventions. He is also working to establish safer vaccines.

    Wakefield remains consistent in his conviction while he is held in high regard by large groups of parents of autistic children, among others, who see him as a champion standing up to the medical industrial complex.

    It might be interesting to note that a recent Stanford Study, as widely reported throughout the mainstream media, acknowledges that “environmental” factors do contribute to the occurrence of autism, leaving the door open for continued research by others about the validity of the original Lancet papers conclusion that gastro intestinal disease & developmental regression might be associated with possible environmental triggers.

  18. [...] Wakefield’s Lancet Paper Vindicated – [Yet Again] [...]

  19. [...] “trolls” defaming these authors and other leading vaccine industry whistleblowers, like Dr. Andrew Wakefield and Dr. Andrew Molden. Wakefield was defamed for linking vaccines to GI disturbances in autistic [...]

  20. [...] “trolls” defaming these authors and other leading vaccine industry whistleblowers, like Dr. Andrew Wakefield and Dr. Andrew Molden. Wakefield was defamed for linking vaccines to GI disturbances in autistic [...]

  21. […] it. The consensus story is a compelling one, but there are many who still believe stories regarding vaccines and autism or dental amalgam and multiple sclerosis, despite refutation or lack of evidence.  We […]

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